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Charles river rats sprague dawley. Bioz Stars score: 86/100, based on 1 PubMed citations.


Charles river rats sprague dawley VITAL SCIENCE S4, E05: Neurogenesis: Regenerating Hope Featured News Charles River Licenses Hera Biolabs' SRG Rat Media Coverage Animal Models to Study Infectious Pathogens A loss of gap-PPI was found in 33% of Wistar, 50% of Sprague Dawley, and 75% of Long Evans rats. Coat Color Use an outbred stock of rat such as the Wistar Han or the Sprague Dawley NTP temporarily switched to the F344/NTac rat and then selected the Wistar Han rat [Crl:WI (Han)]. CD® IGS (Sprague Dawley) Rats Details. 82. Male Sprague-Dawley rats (aged 7-8 weeks The Zucker Diabetic‐Sprague Dawley (ZDSD) rat is an animal model developed for preclinical experimental research on T2D. Harlan. In addition, the effects of restricted feeding of SD rats were also investigated by one facility. We collected behavioral data from 4,625 SD rats acquired predominantly from two commercial vendors, Charles River Laboratories and Harlan Sprague Dawley Inc. Female and male Sprague-Dawley (SD) rats were purchased from Charles River Laboratories (Wilmington, MA, USA). US ()Canada (English/Français)Australia ()Austria (English/Deutsch)Eastern Europe, including the Czech Republic, Hungary, Poland, Slovakia, and Romania (English/Deutsch)France ()Germany (English/Deutsch)Italy ()Ireland ()Israel ()Middle East, including Dubai, Kuwait, and Saudi Nomenclature: Crl:SD Type: Outbred Origin: To SASCO from ARS/Sprague Dawley in 1979. To Charles River in 1996. 5, 1. In 1991, eight colonies Charles River has compiled comprehensive data, such as reproductive, developmental, and juvenile toxicology historical control data, on many of our research animal models. Department of Pathology, University of SPF Sprague–Dawley rats (Crl:CD[SD]) (age, 3 to 6 wk) were purchased from Charles River Laboratories Japan (Tsukuba, Atsugi or Hino Breeding Center, Ibaraki, Kanagawa or Shiga, Japan). In 1980, Harlan Inc. Sprague–Dawley rats and compared them with correspond-ing values from the VC samples. These neurons consistently yield post-thaw viability in the range of 50–80%, have high neuronal purity, and Sprague Dawley producidas en CENPALAB, Cenp: SPRD (Hematological and biochemical parameters in Sprague Dawley laboratory rats breed in CENPALAB, Cenp: SPRD) León Goñi Avelina Caridad | Blanco Diuris | Peña Amelia | Ronda Marisel | González Bárbara O. Charles River Montreal, Canada Results Sprague Dawley rats were noticeably heavier than Wistar rats, where lower bodyweights in Wistar rats were associated with increased survival rates and a lower incidence of spontaneously occurring tumors over a two year period. Despite this, the genetic characteristics of SD rats have not been clearly described, and SD rats are Dawley Inc sprague dawley rats Sprague Dawley Rats, supplied by Dawley Inc, used in various techniques. The original Sprague-Dawley stock was developed from Wistar stock and a hybrid stock produced from laboratory and wild populations. Sprague Dawley Rats and Wistar Han Rats of Similar Ages James Ford, Jr. the challenge in breeding outbred animals is to maintain the diversity at the level IGS Rat Nomenclature: Crl:CD(SD) Strain Code: 001 Origin: Originated in 1925 by Robert W. Upon arrival from Charles River the SD CD rats were Charles River can provide blood products, tissues, and organs collected from VAF/Plus® rats, mice, guinea pigs, hamsters, or gerbils upon request. Letter to the editor. Established in 1925 by Robert Dawley, the original Sprague Dawley rat colony was obtained by Harlan in 1980 through the acquisition of Sprague-Dawley, Inc. and Salt-Resistant (R) rat strains from Sprague Dawley rats which were bred on the basis of their blood pressures after being fed a high salt (8% NaCl) diet3. Try out the SAS Sprague Dawley rat with our animal model evaluation program→. In 1991, eight colonies SD rats are sold by several commercial vendors, including Charles River Laboratories and Harlan Sprague Dawley Inc. The incidence and range of spontaneous thyroid and parathyroid glands findings were determined in control Han-Wistar and Sprague-Dawley rats, and CD-1 mice from 104-week carcinogenicity studies carried out between 1998 and 2010 at Charles River Edinburgh. Fetal outcomes from SS rats and control Sprague–Dawley (SD) rats were also measured. Timed pregnant (n = 13) and virgin (n = 9) SD rats were obtained from Charles River Laboratories (SAS SD, strain code: 400). ZERO BIAS - scores, article reviews, protocol conditions and more Sprague Dawley rats from different vendor colonies display divergent responses in a variety of experimental paradigms. France). Dawley in the 1920s. The search Rats (Rattus norvegicus) are the second-most widely used laboratory animal species after mice, and Sprague Dawley (SD) is one of the most widely employed strains of rat in biomedical research (Krinke et al. In male rats, the age at sexual maturity varies considerably between 40 and 60 days of age. Reference database of the main physiological parameters in Sprague‐Dawley rats from 6 to 32 months. (A) Map of the nine vendor breeding locations and the number of SD rats obtained from each location. Four-week-old male CD rats were acquired from Charles River Charles River France 'VAF - Le Standard International' St. Animals were administered 0, 0. Rats identified as “Sprague Dawley” are sold by several commercial vendors, including Charles River Laboratories and Harlan Sprague Dawley Alemán CL, Más RM, Rodeiro I, et al. The rats were housed at the University of Health Sciences, Laboratory Animals Production and Research Center, with controlled humidity (50% All studies used Crl:CD® (SD)IGS BR rats from four different Charles River Laboratories production sites: Kingston, NY; Raleigh, NC; Portage, MI; or St. Heffelfinger 2, and D. (Crl:SD) Sprague Dawley® Rat An animal, supplied by Charles River Laboratories, cited in 99 publications. | Bada Ana M. DMBA Treatment and Tissue Isolation. Evans, J. Explore why Sprague Dawley ® rats are vital in medical research: Unveiling the Rodent Model Powerhouse: Why Sprague Dawley ® Rats are Essential for Medical Research. The data refer mainly to compiled and published data from breeders and users and include the following strains: F344 (), Harlan Sprague-Dawley strain (Hsd: SD; Weber, Kaiser, and Klein 2012), Charles River, CD rat, Sprague-Dawley-derived (Crl: CD(SD); Charles River 2004), Crl: WI(Han) (Charles River Male (275–299 g) Sprague–Dawley (Harlan) and Fischer 344 (Charles River) rats were allowed 1 week to acclimate to the vivarium. In 1992, Charles River reestablished a foundation colony of SD rats, using 100 breeder pairs from . Gleason, A. All rats were euthanized by exsanguination under anesthesia and tissues weighed. All rats were housed at 12:12-h light-dark cycle, a constant room temperature and 1 Argus Research, A Division of Charles River Laboratories, 905 Sheehy Drive, Bldg. The rats were approximately 38 days of age upon receipt and, following a 7-day acclimation period, were randomly Type: Outbred rat. At 14 d postinoculation, 100% of SD rats shed virus in the feces, and 70% were positive for RTV serum antibodies. In follow-up studies, the origin of the variant phenotype was Charles River research models and services price list. Bioz Stars score: 86/100, based on 1 PubMed citations. Constant, Quebec) were used. Eighty-five adult male outbred Sprague-Dawley rats (2–4 mo old, 230–550 g) from two different suppliers, Harlan (n = 20, Colony 217; Indianapolis, IN) and Charles River Laboratories (n = 65, Colony P09; Portage, MI), were used for this study (referred to as HSD and CRSD, respectively). Mean arterial blood pressure was measured by indwelling femoral catheter in anesthetized SS virgin and SS day 21 late pregnant rats from Charles River Laboratories (CRL). Upon arrival from Charles River the SD CD rats were In order to examine the degree of variability of an outbred stock obtained from various sources, Sprague Dawley (SD) rat lines obtained from two sources were evaluated for their growth characteristics. To Charles River in 1950 from Sprague Dawley, Inc. , Jay Albretsen, Laura Cregar, Gavin Gibson, Steven Denham 1 ABSTRACT Sprague Dawley (SD) rats have been traditionally used in toxicology studies; however, the use of Wistar Han (WH) rats in toxicology studies is increasing due to their smaller size and increased longevity. e. Within the SD strain, SD rats from Charles River exhibited Sprague-Dawley rats. , long-lasting iPMF) when respiratory neural activity was restored. Food and Chemical Toxicology 1985; 23: 355-61. In addition, litters from two developmental neurotoxicology studies were Origin: From Sprague-Dawley stock of an unknown source to Hoechst, Frankfurt. A flexible, ready-to-use, and quality alternative to fresh neurons, each vial contains one million cells per mL. ) Le rat présente de nombreux avantages : il se reproduit rapidement, sa taille facilite le prélèvement d’échantillons et la dissection, et 1 Arterial blood from 63 male (315 - 500 g) and 60 female (210 - 290 g) healthy Sprague-Dawley rats was ana lyzed for 16 hematological and 22 clinical chemistry parameters. AT A GLANCE. SRG Rat. (Malvern, PA, USA) and for the animal studies the rats were maintained under standardized rodent condition at a room temperature Robert S. Less understood is the potential for phenotypic "drift" or variation that is not related to any genetic change. In order to use SD rats to perform a genome-wide association study (GWAS), we collected E18 Sprague Dawley Rat Embryos, supplied by Charles River Laboratories, used in various techniques. We also offer study-ready knockout mouse models for in vivo studies through our collaboration with genOway. 05: Mouse serum: Frozen: 1mL: Mansell, Peter; Hennig, G. The Anx7 targeting vector, the transfection and selection of embryonic stem cells, the preparation of chimeras, and the breeding protocols were as described by Srivastava et al. Review our list The data from Wistar Han rats were compared with those from Sprague Dawley Crl:CD(SD) rats. Note that other sublines of "SD" rats (including SD/A, SD/Cpb, and SD/Waa) are known to differ among themselves, and from this strain (Bender et al 1984 , Festing and Phrenic motor output was recorded in anesthetized, ventilated Harlan (HSD) and Charles River (CRSD) Sprague-Dawley rats exposed to a 30-min central neural apnea. These strains Charles River’s portfolio of research animal models, which includes cardiovascular, metabolic, renal, and oncologic disease models, helps ensure that you will have the Outbred Sprague Dawley rats are among the most commonly used rats for neuroscience, physiology and pharmacological research; in the year 2020, 4,188 publications contained the keyword “Sprague Dawley”. Virgin female Sprague Dawley CD (CD R IGS) rats were purchased at three different ages: weaning (21 days), peri-pubertal (45 days), or mature (100 days) from Charles River Laboratories (all shipments were from either the Portage, MI or Raleigh, NC, breeding facilities). Charles River offers vascular catheterizations in rat, mouse, and guinea pig models from our AAALAC-accredited production facilities. A subset of 4,625 of these rats went 412 A method for regulating the duration of pregnancy and the time of parturition in Sprague-Dawley rats (Charles River CD strain) Dev Psychobiol. Gear 1, M. , 2015 Sprague Dawley (SD) rats are among the most widely used outbred laboratory rat populations. As a result, body weights and food consumption in Wistar Han rats were lower than those of SD rats. In The SRG (Sprague Dawley, Rag2, Il2rg- "SRG") is a severely immunodeficient inbred rat created through knockout mutations in the Rag2 and Il2rgamma genes, resulting in a deficiency in mature B, T, and NK cells. A substrain of Charles River Crl;CD (Sprague Dawley) rats were crossbred with Zucker Diabetic Fatty (ZDF) lean homozygous wild‐type (+/+) rats, which do not carry the leptin receptor mutation (fa) (Peterson et al. Originated in 1925 by Robert W. • Animals were between six and eight weeks of age at the start of treatment. To CRL in 1950 from Sprague Dawley, Inc. 25: $14. The rats were 11 weeks old upon arrival and were P5 Sprague Dawley Rat Pups, supplied by Charles River Laboratories, used in various techniques. Using double-digest genotyping Sprague Dawley ® Wistar; Wistar Han IGS The SRG Rat®: Overview & Xenograft Data Catalog/Price List GSA MAS Price List Related Insights. For example, by A majority of lab rat strains descend from this original colony (Long-Evans/Sprague Dawley). Abstract. Across strains, the most consistent characteristic was a frequency-specific pattern of the loss of gap-PPI, with the highest rates at approximately one octave above trauma. HSD rats expressed a robust, long-lasting (>60 min) increase in phrenic burst amplitude (i. Furthermore, these animals were specifically acquired from different colonies. The Zucker Diabetic-Sprague Dawley (ZDSD) rat is a rodent model developed for experimental studies of T2D. They have been used as a model Sprague Dawley (SD) rats are among the most widely used outbred laboratory rat populations. (now Envigo). ZERO BIAS - scores, article reviews, protocol conditions and more Charles River Sprague Dawley Rats Lack Early Age-Dependent Susceptibility to DMBA-Induced Mammary Carcinogenesis R. , St. 80 (now Envigo, Inc. ZERO BIAS - scores, article reviews, protocol conditions and more Charles River is committed to providing you with high-quality animal models, including mice, rats, guinea pigs, hamsters, gerbils, and rabbits. Rederived into isolator foundation colony in 1997. Charles River Laboratories Subject: Posters: Comparison of Selected Clinical Pathology Parameters in Two Strains of Rats in Different Cage Environments Used in Toxicology Studies Keywords: Clinical Pathology, Hematology, Coagulation, clinical chemistry, Sprague Dawley Rats, Wistar Rats, CD rats, perforated stainless steel floors, polycarbonate Benzoic acid (BA) was administered in the diet to male and female Sprague Dawley Crl:CD(SD) rats in an OECD Test Guideline 443 Extended One-Generation Reproductive Toxicity (EOGRT) study to test for effects that may occur as a result of pre- and postnatal exposure. MATERIALS AND METHODS Animals Male and female specific pathogen-free rats of the Sprague-Dawley strain, Crl:CD(SD), were obtained from Atsugi or Tsukuba Breeding Center, Charles River Laboratories Japan, Inc. n = 8) strains were purchased from Charles River Laboratories (Sulzfeld Sprague Dawley (SD) rats are among the most widely used outbred laboratory rat populations. Survival data from 8 completed cohorts of 100 animals each and one continuing coh DMBA Treatment and Tissue Isolation. 6,8-11 The aim of this retrospective analysis is to compare the In order to examine the degree of variability of an outbred stock obtained from various sources, Sprague Dawley (SD) rat lines obtained from two sources were evaluated for their growth characteristics. In 1991, 8 colonies were selected to form the IGS Wistar female [12]. criver. The animals were purpose Sprague-Dawley Rats Klaus Weber1 Abstract A substantial quantity of data on Sprague-Dawley (SD) and Hannover Wistar rats strains have been published concerning their Crl: CD(SD) ¼ Charles River, CD rat, Sprague-Dawley derived; F344 ¼ Fisher 344; Hsd: SD ¼ Harlan Sprague-Dawley strain; RccHan™: WIST ¼ Wistar Hannover (Han)–derived Recently, stock Sprague-Dawley (Crl:CD(SD)) rats obtained from the Charles River Raleigh facility demonstrated a distinct endogenous urinary metabonomic profile that differed from historical control SD urine spectral profiles obtained over the past several years in our laboratory. , Raleigh, North Carolina. [Google Scholar] 7. Briefly, rats were anesthetized and maintained on 3% isoflurane and a Ponderal growth over days in Sprague Dawley rats obtained from three vendors: Harlan (H; Kent, WA), Charles River (CR; Raleigh, NC), and Simonsen (S; Gilroy, CA). This stock was Trends in survival and body weight were evaluated in 2140 control Sprague-Dawley-derived [Crl: COBS-CD(SD)BR and Crl: COBS-VAF CD(SD)BR] rats used for 24-month rat carcinogenicity studies between 1979 and 1991. Refinements to Intravenous Infusion Systems in Sprague Dawley Rats Aids in the Successful Outcome of a Complex Study Design T. Charles River Breeding Laboratories obtained the stock after CRL had re- established an International Genetic Standard colony. | González Yana | Mancebo Axel. Gibco Primary Rat Cortex Neurons, Sprague Dawley, are isolated and cryopreserved from Sprague Dawley embryonic day-18 rats. (Charles River a débuté il y a 75 ans comme laboratoire d’élevage et a d’abord fourni des rats Sprague Dawley, avant de devenir rapidement le premier producteur d’animaux pour la recherche. Again, variation was noted between performance of rats sourced from different vendors, with Sprague Dawley (SD) rats are among the most widely used outbred laboratory rat populations. Intelligent rat, thus popular model for psychology tests. Coat color: White Strain code: 707 Ideal for:Tumor biology, oncology, immunology, xenograft transplant research Bred in: All experiments were performed in accordance with relevant guidelines and regulations The subjects were male Sprague–Dawley CD, IGS rats (strain #001, Charles River, Raleigh, NC) weighing 225 In order to examine the degree of variability of an outbred stock obtained from various sources, Sprague Dawley (SD) rat lines obtained from two sources were evaluated for their growth characteristics. The SD rats from Charles River laboratories (CRL) and Harlan Laboratories (HAR) were monitored for weight gain from the age of 6 weeks to 24 weeks. (2011). Pregnant female rats (n = 824), rabbits (n = 540), and Recently, stock Sprague-Dawley (Crl:CD(SD)) rats obtained from the Charles River Raleigh facility demonstr Genetic drift in animal populations has been a recognized concern for many years. To Charles River in 1950 animals were obtained from Sprague-Dawley in the 1950s and caesarean rederived by Charles River Laboratories (CRL) to achieve an improved microbiological status. Charles River rats from barrier P03 (Portage, MI) had lower PCA index scores (i. Selective inbreeding produced animals with a predisposition to obesity and a CD® (Sprague Dawley) IGS Rat Originated in 1925 by Robert W. Characteristics: Coat: Albino; Docile disposition; Excellent Originated in 1925 by Robert W. At 23 days of age, rats arrived at the Texas A&M University Kleberg Center animal facilities and then were housed individually in carbonate cages in a temperature- and humidity-controlled room on a The ZDSD rat was developed by cross-breeding the Charles River Laboratory diet-induced obese rats (Sprague-Dawley-derived) with lean ZDF −/− rats. Mated female rats (evidence of spermatozoa Charles River Laboratories first time pregnant sprague dawley rats First Time Pregnant Sprague Dawley Rats, supplied by Charles River Laboratories, used in various techniques. Department of Psychiatry, University of Cincinnati, PO Box 670559, Cincinnati, OH 45267-0559, USA 2. From genetically standard and disease-specific models to surgically altered animals, you can 96 citations – An animal, supplied by Charles River Laboratories. At time of implantation, rats were approximately 9 weeks old and weighed between 202 and 285 g. 1 Male Sprague-Dawley rats were obtained from Charles River Laboratories. Relationship of body-weight gain to longevity and to risk of development of nephropathy and neoplasia in Sprague-Dawley rats. Clinical Laboratory Parameters for Crl:WI(Han) Rats ‐ Charles River. 3 Department of Veterinary Biosciences, Faculty of Veterinary and Agricultural To test the effect of escalating and very high doses of oral PIC, male Sprague-Dawley rats were gavaged PIC: Group 1 (n = 3) received incremental doses of 125, 250 and 500 mg/kg/day PIC on days 1, 3 and 5. A, Horsham, PA 19044, USA. Oxygen-induced retinopathy was induced with the rat 50/10 model. For RUPP rats, pregnant animals were received on GD11 and subjected to aortic and bilateral uterine artery constriction on GD14. Please read the appropriate set of Terms and Conditions based on your country. Despite their wide spread use, little is known about the genetic Author Summary Outbred Sprague Dawley rats are among the most commonly used rats for neuroscience, physiology and pharmacological research; in the year 2020, 4,188 publications contained the keyword “Sprague Dawley”. Yan 1, J. Charles River Laboratories and Harlan Sprague Dawley Inc. In 1950, Charles River Inc. Schneider 1, P. Shaffer, M. Mice have traditionally been considered choice research models because their embryonic stem cells are more robust than those of rats. L’un des tout derniers descendants de cette souche est le rat SRG OncoRat, un rat consanguin hautement immunodéficient, particulièrement utile pour la recherche sur le cancer, les maladies Sprague Dawley ( SD ) rats are one of the most commonly used outbred rat strains. 2 METHODS Animals: • Sprague Dawley ® CD IGS (Crl: CD[SD]) and Wistar (Han) IGS (Crl: WI [Han]) rats obtained primarily from Charles River, Quebec, Canada used as control animals. After a baseline period of growth, half of the animals from each vendor were given ad libitum 32% sucrose solutions and lard PDF | Developmental stages of mammary glands influence their susceptibility to initiating events related to carcinogenesis. 4 Charles River Laboratories Inc, 4025 Stirrup Creek Dr. Despite this, the genetic characteristics of SD rats have not been clearly described, and SD rats are rarely used for experiments aimed at exploring genotype-phenotype relationships. ZERO BIAS - scores, article reviews, protocol conditions and more Male 5 week old Sprague Dawley rats from Charles River (CRL:CD(SD) originating from Portage, MI and Harlan Hsd:Sprague Dawley (SD) SD rats originating from Haslett, MI, Barrier 206, were housed in an AAALAC accredited, Specific Pathogen-Free laboratory animal facility. Fifteen‐week‐old male outbred Sprague Dawley (SPD, n = 16) and Zucker Diabetic‐Sprague Dawley rats (n = 16) were purchased from Charles River (Wilmington, MA, USA). Charles River's Developmental and Reproductive Toxicology team have an extensive collection of publications, posters/abstracts and presentations. Sprague-Dawley rats (70 males and 67 females; Charles River Canada Inc. Founder animals were obtained from Sprague-Dawley in the 1950s and caesarean rederived by Charles River Laboratories (CRL) to achieve an improved microbiological status. 2 Citoxlab-Charles River Company, Ejby, Denmark. 8% kcal from fat) for 2 weeks to induce a CR Charles River DOI 2,5-Dimehot xy-4-iodoampheaminet NMDA N-mel-D-asparyh t atet PPI Prepulse inhibition SC Subcutaneously SD Sprague Dawyle Introduction Rats (Rattus norvegicus) are the second-most widely used laboratory animal species after mice, and Sprague Dawley (SD) is one of the most widely employed strains of rat in Historical control data from reproductive and developmental toxicity studies in Sprague-Dawley (SD) rats and New Zealand White (NZW) rabbits as well as the spontaneous incidence of congenital malformations and variations in the Göttingen minipig have been previously reported. Sprague Dawley Rats E19, supplied by Charles River Laboratories, used in various techniques. CD® IGS Rats NOMENCLATURE: Crl:CD(SD) research models Strain Origin Originated in 1925 by Robert W. began to distribute SD rats. Transferred to To SASCO from ARS/Sprague Dawley in 1979. Seventy-five years ago, Dr. Publications between 2009 and 2021 (last search updated June 2021) were included in the study. Try out the SAS Sprague Dawley rat with our animal model evaluation program→Note: We also offer the CD® Type: Outbred rat. N. These studies are yet unpublished, but the The SRG (Sprague Dawley, Rag2, Il2rg- "SRG") is a severely immunodeficient inbred rat created through knockout mutations in the Rag2 and Il2rgamma genes, resulting in a deficiency in mature B, T, and NK cells. For each perifusion run the appropriate number of animals are killed by decapitation. ; Copeman, C. Ltd. and skeletal malformations and variations across species in the Sprague-Dawley rat, New Zealand White rabbit, and Göttingen minipig and to determine whether notable differences exist. Bultman Charles River, Ashland Ohio 4 CONCLUSIONS 1 ABSTRACT 3 RESULTS The Infusion Department at Charles River Ashland was given a challenge: administer a 15 Groups of Sprague-Dawley CD rats (20 per sex; Charles River Laboratories, Portage, MI) were administered the test material Groups of 25 pregnant Sprague-Dawley rats received 0 ppm (control), 5,000 ppm, 25,000 ppm, or 50,000 ppm of the test material in diet ad libitum on day 6 (am) through day 15 (pm) La plupart des souches de rats de laboratoire, telles que les souches Long-Evans et Sprague Dawley, sont issues de la colonie d’origine Wistar. PMID: 12378951 Crl Sprague-Dawley rats were evaluated for consistency with both historical observations and published values from other laboratories. ZERO BIAS - scores, article reviews, protocol conditions and more. Materials and methods Animals Forty-six male Sprague–Dawley (Crl:CD(SD)) rats were obtained from Charles River Laboratories (L’Arbresle, Laboratory Animals 2010; 44: 344–351. L. On gross examination, the majority of Sprague–Dawley rats that died during or shortly after MCAO had solid, stiff hearts and sometimes hemorrhagic lungs. Succop 3, S. Dose levels were selected based on a range-finding study showing mortality in parents and Although minor but significant differences were found between paired adrenal gland:body weight ratios for the dry gavage and singly housed gavaged rats, the overall range of relative adrenal gland weights obtained in this study are within the normal range seen for Charles River Sprague–Dawley rats of this age 16 and were interpreted to be ous clonic convulsions in Charles River SD rats from 11 carcinogenicity studies conducted at our laboratory. 1998;32:457‐466. Thereafter, two animals from each strain were randomly selected to serve as weight controls, and the remaining animals were food restricted until they were at 85% of the controls’ weight. | Arteaga María E. colonies. In 1991, eight colonies the challenge in breeding outbred animals is to maintain the diversity at the level IGS Rat Nomenclature: Crl:CD(SD) Strain Code: 001 Origin: Originated in 1925 by Robert W. Adult male and female Sprague–Dawley CD rats (Charles River, Portage, MI) are used for all experiments. Sprague Dawley-Rag2 em2hera Il2rg em1hera /HblCrl. In females estrous-stage cycle is assessed by vaginal cytology and presence of intraluminal water in the uterus. Prior to purchase they received filtered tap water, were fed Agway 4018 (Agway, Waver-ley Male-Sprague-Dawley rats (CrL:CD(SD)BR) were maintained under barrier conditions at Charles River Breeding Laboratories (Wilmington MA) from August, 1975, to July, 1983. Despite this, the genetic characteristics of SD are poorly understood. Animals were provided food and water ad libitum. SD and other lines such as Long-Evans and Wistar are available from an array of biotechnology companies, including Envigo (formerly known as 1 Citoxlab-Charles River Company, Laval, Canada. D. • Animals were group or individually housed in Sprague Dawley rats Graph 4: Group mean body weights; group vs individually housed Wistar rats The data used for collation comprised: 13 Han Wistar (HW) rat studies (16 control groups of 879 males and 879 females in total) obtained from Harlan (UK) Limited, Envigo RMS (UK) or Charles River (UK) Limited; 13 Sprague-Dawley (SD) rat studies (13 control groups of 876 males in total, and 15 control groups of 1,016 females in total) obtained from Charles River (UK) Limited. Several studies, however, have found significant behavioral and physiological differences between Sprague Dawley (SD) rats from separate vendors. In fact, Sprague Dawley rats are available in two sub-strains, one (originated by Charles River Laboratories, Wilmington, MA), which gains less weight than the other (originated by the Sprague Dawley Company, Madison, WI). In 1991, 8 colonies were selected to form the Popular rat to function as foster parents in caesarean procedures. Sprague-Dawley or Wistar Hannover rats when comparing diets containing 14% or 18% protein content in studies up to 2 -years in duration. An adjuvant-induced arthritis (AA) model of human rheumatoid arthritis was used to examine immune and endocrine responses to inflammatory challenge in Sprague Dawley rats from Charles River and Harlan colonies. Caesarean rederived in 1955 from original Charles River Sprague Dawley. R. Roe Fjc. 1998 Mar;32(2):131-6. 81. Coat color: White (albino) Strain code: 400 Ideal for: General multipurpose model, safety and efficacy testing, aging, nutrition, diet-induced obesity, oncology, surgical model Nomenclature: Sprague Dawley-Rag2 em2hera Il2rg em1hera /HblCrl Type: Inbred rat, genetically engineered, immunodeficient Origin: The SRG rat was transferred from Transposagen to Hera Biolabs in 2016. Clegg 1 1. ) began to distribute SD rats after their acquisition of Sprague- Dawley, Inc. To Charles River in 1996. " 2 The most recent publication examined the pilocarpine model of temporal lobe epilepsy. Reagent Search & Data Services Menu Reagent Search. 2015 CHARLES RIVER LIST PRICE 2015 CUSTOMER PRICE Sprague Dawley® Rats when ordering, specify SAS SD MALE Prices upon request Prices upon request www. In 1991, eight colonies HEMATOLOGY PARAMETERS FOR THE CrI:CD®BR RAT Normal or "expected" values for hematology and serum chemistry are frequently sought by those wishing to compare values assayed in their Charles River Laboratories jvc male sprague dawley rats Jvc Male Sprague Dawley Rats, supplied by Charles River Laboratories, used in various techniques. Female rats were mated at the testing facility. Animals. Authors A D Rats, Sprague-Dawley Time Factors Grant support GM008233/GM/NIGMS NIH HHS/United States generation Reproductive Toxicity Study (EOGRTS) of amitraz was recently completed in Sprague-Dawley rats using the gavage route of dosing. various existing colonies [14]. Prepulse inhibition of startle (PPI), a form of sensorimotor gating in which a low-intensity leading stimulus reduces the startle response to a subsequent stimulus, may also vary by vendor. In 1991, 8 colonies were selected to form the IGS Foundation Originated in 1925 by Robert W. 2 Nine of these The exact timing of puberty is fundamental in preclinical studies. J. Room air control and oxygen-induced retinopathy groups were compared. 2000). Some Male and female Sprague-Dawley [Crl:CD(SD)IGS BR VAF/Plus] rats were supplied by Charles River Laboratories (Raleigh, NC). Stamen, J. Considering the impact of reproductive complications in the Sprague–Dawley rat, Dr. Durham, NC, 27703, USA. The Hsd:Sprague Dawley ® SD ® rat has a wide array of historical research use including in the field of cardiology Charles River Laboratory Subject The objective of this study was to qualify procedures for continuous intravenous infusion of saline via a surgically implanted catheter following surgical procedures to neonatal Sprague Dawley rats starting on Day 21 post partum for 35 days \(to day 57 po\ stpartum\). We reviewed the scientific literature reference lists of publications listed by Charles River’s technical sheets for the ZDSD rat. [13]. Male 5 week old Sprague Dawley rats from Charles River (CRL:CD(SD) originating from Portage, MI and Harlan Hsd:Sprague Dawley (SD) SD rats originating from Haslett, MI, Barrier 206, were housed in an AAALAC accredited, Specific Pathogen-Free laboratory animal facility. , between 12 May 2003 and 18 In a study to evaluate mineral and fat-soluble vitamin status in male Charles River Japan Sprague Dawley rats, exposure to a diet containing 5% chitosan for 2 weeks caused a decrease in mineral absorption and bone mineral content. Dawley from a hybrid hooded male and a female Wistar rat. The study involved 40 male Sprague‒Dawley rats selectively bred from the original lineage obtained from Charles River Laboratories (Charles River Laboratories, Research Models and Services, Germany GmbH). To Charles River from Hera Biolabs in 2021. B. Despite this, the genetic characteristics of SD rats have not been clearly described, and SD rats are Sprague Dawley ( SD ) rats are one of the most commonly used outbred rat strains. (Charles River). To O. -Aubin-les-Elbeut, France: Charles River France, 1989. 5, or 7. Ever since the innovation of the Wistar rat and the many other rat strains that have descended from it, rats have given so much to helping us understand the human body and its inner workings. Henry Foster, fresh out of veterinary school, purchased several thousand The incidence and range of spontaneous central nervous system tumors were determined in control Charles River rodents (Sprague-Dawley, Han-Wistar, Wistar rats, and CD-1 mice) from regulatory carcinogenicity studies carried out over the period 2002 to 2013 and were compared with the previously published data. Make sure to thank our furry little friends next time you see 408 Methods 409 Sprague Dawley samples 410 Tissue samples from 5,206 male Sprague Dawley rats were obtained, predominantly from 411 Charles River and Harlan, with a few samples from Taconic. com CHARLES RIVER RESEARCH MODELS AND SERVICES | US 2015 FEMALE MALE FEMALE CD® Hairless Rats Socially Housed Sprague Dawley Female Rats Marilyne Boyer, Julien Jouniaux, Aurore Varela, Susan Y Smith, Charles River Montreal, Quebec, Canada 4 Conclusion In conclusion, there are no meaningful differences in Area, BMC and BMD values noted between single and socially housed female Sprague Dawley rats, therefore, housing Oral inoculation of Sprague–Dawley (SD) and CD male rats (n = 10 each group) with RTV1 revealed that SD rats were more susceptible than CD rats to RTV1 infection. Rats were approximately 60 days of age upon arrival. In order to use SD rats to perform a genome-wide association study (GWAS), we collected Wistar female [12]. Lastly, we demonstrate this strain of virgin female rats has elevated pituitary prolactin immunoreactivity independent of the level of mammary differentiation. Goulopoulou and her team at the University of North Texas Health Science Center consistently observed adverse perinatal outcomes in pregnant SD rats bred in-house through 2019 and early 2020. In 1991, 8 colonies were selected to form the Wistar (Han) IGS (Crl: WI [Han]) rats obtained primarily from Charles River, Quebec, Canada used as control animals. Trunk blood is collected and the serum Genetic architecture of SD rats from Charles River vs. After quarantine and acclimation periods of 1 to 2 wk, ophthalmologic examinations of 2033 male (42 lots) and 1322 female (32 lots) rats were conducted at our Adult male Sprague-Dawley rats (250–300 g) were purchased from either Charles River (n = 115) or Harlan (n = 442). In 1991, 8 colonies were selected to form the IGS Foundation Colony. Rats identified as “Sprague Dawley” are sold by several commercial vendors, including Charles River Laboratories and Harlan Sprague Type Sprague Dawley E18 Embryonic Rats, supplied by Dawley Inc, used in various techniques. Rats: CD ® (Sprague Dawley) Blood Product Format Size Price (USD) Price (CAD) Mouse plasma (K2ETA) Frozen: 1mL: $10. However, in several studies with perinatal exposure, the average litter sizes were smaller than expected, the litters had a high variability in sex distribution, and Sprague Dawley (SD) rats are among the most widely used outbred laboratory rat populations. Using double-digest genotyping We would like to show you a description here but the site won’t allow us. Rederived into Forty one male Sprague-Dawley Crl:CD(SD) rats were obtained from Charles River Canada Inc. (2) Sprague Dawley rats, developed from Wistar rats, have an adult weight of up to 300 g [5] and are one of the breeds most widely used in pre-clinical studies [78]. , more goal-tracking behavior) than rats from barrier P09 Genetic Engineering and Laboratory Rats. The incidence of clinical signs Sprague Dawley (SD) rats are an outbred stock originally developed from Wistar rats crossed with a variety of other laboratory and wild rats. Animals were housed individually in polycarbonate bins equipped with an automatic watering valve and appropriate bedding material. (SD), were obtained from Charles River Laboratories, Inc. We conclude this strain of Charles River Sprague Dawley rats has prolactin-induced pituitary stimulation, and therefore, the window of susceptibility for mammary tumorigenesis is absent. Rats were housed in pairs in a controlled environment (12 h light/dark In addition, Sprague–Dawley rats purchased from Harlan did not differ from those obtained from Charles River for any parameter. Female rats were approximately 59 days old at arrival and only female rats were treated; untreated male rats, approximately 73 days old at arrival, were used only as breed-ers. Haferkamp, University of Ulm, to ITRI-TNO Rijswijk, The Netherlands in 1972 (van Hooft 1990). C. Lab Anim. Outbred rat strains such as Sprague-Dawley (SD) or Wistar are widely used in epilepsy models, including popular models of temporal lobe epilepsy in which spontaneous recurrent seizures (SRS), hippocampal damage, and behavioral alterations develop after status epilepticus (SE). Furthermore, Sprague-Dawley rats from Charles River Laboratories were the only strain that did not develop neurodegeneration in the hippocampal formation after SE. Origin: Originated in 1925 by Robert W. But advances in genetic editing tools such as CRISPR-Cas9* and the use of engineered endonucleases make it possible to precisely target the rat genome. 5 mg/kg of technical grade amitraz daily for nine weeks and then mated. in the CD-COBS rats used during 1979-1987 Fat, frail and dying young: survival, body weight and pathology of the Charles River the challenge in breeding outbred animals is to maintain the diversity at the level IGS Rat Nomenclature: Crl:CD(SD) Strain Code: 001 Origin: Originated in 1925 by Robert W. ZERO BIAS - scores, article reviews, protocol conditions and more Methods: We analyzed retinal vascular morphometry and transcriptomes from Sprague Dawley rat pups from Charles River Laboratories and Envigo (previously Harlan). Our highly skilled animal surgeons can provide you with study-ready animals where and when Sprague-Dawley Rats Klaus Weber1 Abstract A substantial quantity of data on Sprague-Dawley (SD) and Hannover Wistar rats strains have been published concerning their Crl: CD(SD) ¼ Charles River, CD rat, Sprague-Dawley derived; F344 ¼ Fisher 344; Hsd: SD ¼ Harlan Sprague-Dawley strain; RccHan™: WIST ¼ Wistar Hannover (Han)–derived The SD rats from Charles River laboratories (CRL) and Harlan Laboratories (HAR) were monitored for weight gain from the age of 6 weeks to 24 weeks. Constant, Quebec, Canada as the parental (F0) generation. Google Scholar. Thus, a 300 g male Sprague Dawley rat can be between 57 and 70 days of age, depending on the vendor and colony (Charles Follow the history of Charles River, from its modest beginnings to a valued and innovative partner in drug development. The rats’ sentinels were negative for the most common rodent diseases. ZERO BIAS - scores, article reviews, protocol conditions and more Adult male Sprague–Dawley rats (300–350 g) were obtained from Charles River. The rats in these studies were from control groups of dietary or gavage studies. Harlan became Envigo in 2015, then Envigo was acquired by Inotiv in 2021. 26 Decreased serum vitamin E was observed in rats fed 5% chitosan with ascorbic acid supplementation in the diet Sprague-Dawley rats were obtained from Charles River Laboratories and were euthanized by carbon dioxide inhalation followed by a Testing Facility SOP-approved method to ensure death in accordance with Based on observed phenotypic differences in growth and ACTH responses to stress in Sprague Dawley rats obtained from different vendors, we ran head-to-head comparisons on rats obtained from three different vendors, Harlan, Charles River, and Simonsen, with respect to baseline phenotypic differences and a metabolic feedback hypothesis of hypothalamo 2 Charles River Laboratories, Senneville, QC, Canada. The "window of | Find, read and cite all the research you need on This article is an update of Weber, Razinger, et al. [13] . Using To examine the in-vivo release profile, approximately 200 g male Sprague Dawley (SD) rats and for the in-vivo efficacy another group of male Sprague Dawley rats (180–200 g, age 4–6 weeks) were purchased from Charles River Laboratory Co. Here, we summarize pubertal onset evaluation of two outbred rat strains (Crl:CD(SD) and Crl:LE), relying on In this study, pituitary gland samples from a total of 2,536 rats (1,869 Han-Wistar [Crl:WI(Han)] 667 Sprague-Dawley [Crl:CD(SD)]) and 2,361 CD-1 mice [Crl:CD-1(ICR)] were obtained from control groups of twenty-eight 104-week carcinogenicity studies conducted between 1998 and 2010 at Charles River Edinburgh (Table 1). At 16 weeks of age, both SPD and ZDSD rats were provided a high‐fat diet (Research Diets Inc, New Brunswick, NJ, USA; #D12468, 28. nfoyic ynp icehpl hgkzpp asrjzf wskhgpy moii eobu kdp vuvw